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Name	Brief Description	Main Ingredient	Lasts for*	Dissolvable?	Cost per unit	HA concentra-tion	Best For	Side effects and risks
Temporary fillers. Hyaluronic Acid based fillers
Juvederm family of fillers. Made by Allergan
JUVÉDERM Ultra XC	Dissolvable, homogenous highly cohesive HA gel, 9% cross-linked; hydrophilic	Hyaluronic Acid and BDDE	6 - 12 months	Yes	$450 - $700 per 1 ml syringe	24 mg/ml	NLF, Marionette lines	None/rare**
JUVÉDERM Ultra Plus XC	Dissolvable, homogenous highly cohesive HA gel, 11% cross-linked; hydrophilic	Hyaluronic Acid and BDDE	6 - 12 months	Yes	$450 - $700 per 1 ml syringe	24 mg/ml	NLF, Marionette lines	None/rare**
JUVÉDERM VOLBELLA® XC Vycross Technology	Dissolvable, homogenous HA gel, non-hydrophilic	Hyaluronic Acid and BDDE	6 - 12 months	Yes	$350 - 500 per 0.5 ml syringe	15 mg/mL	Lips	None/rare**
JUVÉDERM VOLLURE™ XC Vycross Technology	Dissolvable, homogenous HA gel, non-hydrophilic	Hyaluronic Acid and BDDE	12-18 months	Yes	$550 - $800 per 1 ml syringe	17.5 mg/mL	NLF, Marionette lines	None/rare**
JUVÉDERM VOLUMA® XC Vycross Technology	Dissolvable with an effort, homogenous HA gel, non-hydrophilic	Hyaluronic Acid and BDDE	Up to 24 months	Yes, but not well	$800 - $1200 per 1 ml syringe	20 mg/mL	Volume and contour: Temples, cheekbone, anteromedial (apple) and medial cheeks	None/rare**
Restylane family of fillers. Made by Galderma Laboratories
Restylane Silk (Restylane Fine Lines in Canada)	Dissolvable, homogenous HA gel, non-hydrophilic with very tiny HA particles	Hyaluronic Acid and BDDE	Up to 6 months	Yes	$400 - $800 per 1 ml syringe	20 mg/ml	Lips and around the mouth; superficial injections in the skin	None/rare**
Restylane	Dissolvable, homogenous HA gel, non-hydrophilic, medium size HA particles	Hyaluronic Acid and BDDE	Up to 18 months	Yes	$400 - $800 per 1 ml syringe	20 mg/ml	Under the muscle under the eye; NLF, Marionette lines; lips	None/rare**
Restylane-L	Dissolvable, homogenous HA gel, non-hydrophilic, medium size HA particles	Hyaluronic Acid and BDDE	Up to 18 months	Yes	$400 - $800 per 1 ml syringe	20 mg/ml	Under the muscle under the eye to restore volume; NLF, Marionette lines; lips	None/rare**
Restylane Refyne	Dissolvable, homogenous HA gel, non-hydrophilic, XpresHAn cross-linking	Hyaluronic Acid and BDDE	Up to 12 months	Yes	$400 - $800 per 1 ml syringe	20 mg/ml	Mobile areas of the face; NLF and Marionette lines	None/rare**
Restylane Defyne	Dissolvable, homogenous HA gel, non-hydrophillic , XpresHAn cross-linking	Hyaluronic Acid and BDDE	Up to 12 months	Yes	$400 - $800 per 1 ml syringe	20 mg/ml	Mobile areas of the face; NLF and Marionette lines	None/rare**
Restylane Lyft (formerly Perlane-L)	Dissolvable, homogenous HA gel, non-hydrophilic; very large HA particles	Hyaluronic Acid and BDDE	Up to 18 months	Yes	$500 - $1,000 per 1 ml syringe	20 mg/ml	Volume and contour: Temples, cheekbone, anteromedial (apple) and medial cheeks	None/rare**
Belotero family of fillers. Made by Merz Aesthetics. In the USA, only Belotero Balance is approved
Belotero Balance	Dissolvable, homogenous HA gel, non-hydrophillic	Hyaluronic Acid and BDDE	Up to 6 months	Yes	$500 - $800 per 1 ml syringe	22.5 mg/ml	Lips, around mouth, under the eyes	None/rare**
Revanesse family of fillers. Made by Prollenium, Canada. In the USA, only Revanesse Versa is approved
Revanesse Versa	Dissolvable, homogenous HA gel, non-hydrophillic	Hyaluronic Acid and BDDE	Up to 12 months	Yes	$500 - $800 per 1 ml syringe	25 mg/ml	NLF, Marionette lines, lips	None/rare**
Temporary Fillers. Non-HA fillers
Radiesse	CaHA based filler; immediate volume from the gel, then CaHA gradually stimulates own collagen production. Made by Merz	Microspheres of Calcium Hydroxylapatite (CaHA) in an aqeous gel carrier	Between 12 and 18 months	No	$300-$600 per 0.8 ml syringe; $400 - $ 1,000 per 1.5 ml syringe	N/a - non HA filler	NLF, Marionette lines, deep wrinkles, volume restoration	None/rare**
Sculptra Aesthetic	PLLA based filler; stimulates own collagen production; 2-3 treatments req'd 3 - 6 weeks apart; gradual results. Made by Galderma.	Synthetic Poly-L-Lactic Acid (PLLA)	Up to 24 months	No	$600 - $900 per vial	N/a - non HA filler	NLF, deep wrinkles, volume restoration	None/rare**
Semi-Permanent and Permanent Fillers
Allofill	Permanent/ semi-permanent filler made of donated human fat	Cleansed human fat tissue	Permanent/ semi-permanent	No	$ 1,500 - $2,000 per 3.0 ml syringe	N/a - non HA filler	A natural filler for any area of the face	Only mild temporary
Bellafill (former Artefill)	Semi- permanent synthetic filler gel based on PMMA (polymethyl-methacrylate microsphere)	20% synthetic PMMA and 80% purified bovine collagen	1 to 5 years	No	$ 800 - $ 1,200 per 0.8 ml syringe	N/a - non HA filler	Pitted acne scars; NLF	Nodule formation/lumpiness
Silikon-1000	Synthetic silicone gel that can only be removed surgically and is used as a filler off-label	Synthetic Silicone	Permanent	No	$500 - $1,300 per treatment area	N/a - non HA filler		The risk of migration and lumps; would require surgical removal

 

Fillers are cosmetic products that are injected either in the skin or in one of the facial layers under the skin (see the anatomical layers of the face) to restore volume, correct lines and wrinkles, or enhance facial features.

All the fillers –

• share the treatment method: they are injected from a syringe with either a needle or a canula. The treatment does not include any surgical cutting and is considered minimally invasive;
• do not require general or local anesthesia (possibly, topical numbing only);
• have no downtime except for some rare and only minor redness, swelling and bruising ;
• with most fillers, the results are immediate.​

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Notes and Explanations

* From numerous observations by patients and medical professionals, repeat treatments result in longer duration compared to the initial injections. After your second or third treatment, that same filler in the same area may now last up to 12-36 months (versus the original 4 to 24 months) (Smith SR; 2010)

** None/rare side effects - with all injections of Hyaluronic Acid fillers some minor redness, swelling and minor bruising sometimes occur. They go away on their own within several days. 
​
NLF - nasolabial fold (nose to mouth fold)

​Hydrophilic - attracts water. It is possible that after an injection, depending on how well hydrated you are or depending on the water retention level in your body on a given day, the injection area will look bigger or smaller. This effect of varying size and prominence is particularly undesirable in the lips and under the eyes. 

BDDE stands for 1,4-butanediol diglycidyl ether. In the majority of the hyaluronic fillers in Europe and all the hyaluronic fillers approved in the USA, the molecules of the HA in the filler gel are cross-linked with BDDE. Free, unlinked HA molecules would be metabolized by the body fast. Cross-linking is necessary to make the HA filler gels last longer. 

Syringe size/volume - cc is the same as ml (1 cc is the same volume as 1 ml)

Dermal filler is actually a misnomer as fillers may be placed in different layers of the face (see the facial anatomy layers here) depending on the corrected problem, technique and the type of filler.

More about different filler families
​
Juvederm's Vycross technology, which combines longer HA chains having a high molecular weight with shorter chains that have a lower molecular weight. This is unlike the earlier generation of fillers by Allergan, regular Juvederm, where the cross-linked HA chains were of uniform molecular weight. 

​Older Restylane products rely on higher G Prime and particle size to achieve higher lift. These products are based on HA particle dimension, which is established through a sizing process during the division of the gel.
The two new Restylane products - Restylane Defyne and Restylane Refyne - use XpresHAn technology of cross-linking the molecules of Hyaluronic acid. XpresHAn creates a smooth gels that allows maintaining natural movement and expression.
​
CPDM - Cohesive Polydensified Matrix is a technology patented by Merz and used to create their Belotero range of Hyaluronic Acid fillers. CPDM produces a very homogenous soft-flowing gel that should allow a more even integration into a facial tissue, which leads to favorable esthetic results (Kuhne U., 2016). 

All fillers are good for hands, even though the only one officially approved for the hands in the USA is Radiesse. The injection technique is what makes the difference. HA fillers will provide temporary volume and hydration. Radiesse will stimulate long-term collagen production.